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Mithramycin A

CAS No. 18378-89-7

Mithramycin A( Plicamycin | PA 144 | NSC 24559 )

Catalog No. M12838 CAS No. 18378-89-7

A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mithramycin A
  • Note
    Research use only, not for human use.
  • Brief Description
    A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.
  • Description
    A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Plicamycin | PA 144 | NSC 24559
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    18378-89-7
  • Formula Weight
    1085
  • Molecular Formula
    C52H76O24
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (92.15 mM)
  • SMILES
    O=C1[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@@H](O[C@H]4C[C@](C)(O)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[C@H](O)[C@@H](C)O2)[C@H]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)CC5=C1C(O)=C6C(O)=C(C)C(O[C@H]7C[C@@H](O[C@H]8C[C@@H](O)[C@H](O)[C@@H](C)O8)[C@H](O)[C@@H](C)O7)=CC6=C5
  • Chemical Name
    (2S,3S)-3-((1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Boro A, et al. Int J Cancer. 2012 Nov 1;131(9):2153-64. 2. Lee TJ, et al. Mol Cancer Ther. 2006 Nov;5(11):2737-46. 3. Majee S, et al. Biochem Pharmacol. 1999 May 1;57(9):981-7.
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